Inhaled corticosteroid dose-response on blood eosinophils in asthma.
نویسندگان
چکیده
منابع مشابه
Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma
BACKGROUND Recent efficacy studies of asthma biologics have included highly enriched patient populations. Using a similar approach, we examined factors that predict response to omalizumab to facilitate selection of patients most likely to derive the greatest clinical benefit from therapy. METHODS Data from two phase III clinical trials of omalizumab in patients with allergic asthma were exami...
متن کاملAlterations in airway inflammation and lung function during corticosteroid therapy for atopic asthma.
INTRODUCTION Although corticosteroid therapy for asthma improves lung function and reduces airway inflammation, the relation between these two events is unclear. This article investigates associations between changes in bronchial inflammation and lung function during high-dose inhaled corticosteroid therapy for asthma. METHODS Nine subjects with atopic asthma received high-dose inhaled flutic...
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Sputum eosinophilia is a sensitive predictor of benefit from corticosteroid treatment. Montelukast is a cysteinyl leukotriene antagonist, which also reduces sputum and blood eosinophils. The present study examined the possibility that montelukast has an added eosinophil-lowering effect in subjects with asthma who are corticosteroid responsive but relatively corticosteroid resistant. A total of ...
متن کامل[Localization and expression of Slingshot-1L in peripheral eosinophils from patients with acute asthma exacerbation].
OBJECTIVE Eosinophils play a pivotal role in asthmatic airway inflammation. We previously found a significantly high expression of Slingshot-1L (SSH-1L) in peripheral eosinophils in acute exacerbations of asthma. Objective To investigate the expression and localization patterns of SSH-1L in peripheral blood eosinophils of asthmatic patients and their changes after treatment with inhaled cortico...
متن کاملاثربخشی زنجبیل در بیماران مبتلا به آسم
Background and purpose: The goal of asthma therapy is to achieve clinical control and near normal lung functions. Many patients with moderate persistent asthma fail to achieve this goal with a low dose of inhaled corticosteroid (ÏÇS) plus long-acting β2 agonist (LÂBÂ). Ïn the present study, we have checked whether another controller medication (in the form of ginger capsule) add on to ÏÇSlow do...
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عنوان ژورنال:
- The Lancet. Respiratory medicine
دوره 4 1 شماره
صفحات -
تاریخ انتشار 2016